ST. LUKE'S-ROOSEVELT HOSPITAL CENTER ADVANCES NEUROSURGICAL TREATMENT OF CRANIAL BASE TUMORS AND SPINE DISORDERS

SUCCESS RECORD OF SURGICAL TEAM OFFERS PATIENTS ADVANCED TREATMENT AND HIGHER CHANCE TO RECAPTURE FUNCTION AND COSMETIC AESTHETICS FOLLOWING COMPLEX CRANIO-FACIAL SURGERY

With the appointment of Chandranath Sen, M.D., as Chairman of the Department of Neurosurgery, and Co-Director of the Center for Cranial Base Surgery, St. Luke's-Roosevelt Hospital Center (SLR) launches a new era in the neurosurgical treatment of cranial base tumors and other complex neurosurgical problems. Tumors of the skull base -- including craniofacial tumors, and tumors behind or beneath the nose or eyes -- are hard-to-reach, and generally represent such formidable surgical challenges that many surgeons consider such lesions to be inoperable.

Dr. Sen, also Interim Chairman of the Department of Neurosurgery at Beth Israel Medical Center, is one of the world's most accomplished neurosurgeons in this intricate, highly challenging specialty. His skills enable most patients to emerge from these challenging surgeries with fewer complications and a higher chance of recapturing function and cosmetic aesthetics. Dr. Sen is also highly experienced in surgery for acoustic neuromas, and treatment of trigeminal neuralgia and hemifacial spasm.

Dr. Sen is formerly Professor and Vice Chairman of Neurosurgery at Mount Sinai Medical Center. He and his colleagues Noel I. Perin, M.D., FRCS (Ed), FACS, and Peter D. Costantino, M.D., FACS (otolaryngology), also formerly of Mount Sinai, will work as a coordinated team, providing superb medical care while continuing innovative research to advance the neurosurgical field. "Our vision is to create an advanced, interdisciplinary neurosurgical department at SLR," says Dr. Sen, "where we can provide patients with state-of-the-art treatment of brain and skull base tumors and many other neurosurgical problems, and restore their quality of life by returning function and facial aesthetics. We will work closely with Beth Israel's Institute of Neurology & Neurosurgery (INN) to provide world-class comprehensive neurosurgical care."

Noel I. Perin, M.D.: Minimally Invasive Spine Center
St. Luke's-Roosevelt's expanded neurosurgical services will encompass a Minimally Invasive Spine Center under Dr. Perin, Director of Spine Surgery. He is a pioneer in developing closed, endoscopic surgical techniques for treatment of the spine and spinal cord, including traumatic, neoplastic, degenerative, congenital and inflammatory conditions. Dr. Perin also among the world's few surgeons to perform endoscopic thoracic surgery, resulting in less post-operative pain and faster recovery time. He is formerly Associate Professor of Neurosurgery and Director of Spinal Surgery at the Mount Sinai School of Medicine and at New York University.

Peter D. Costantino, M.D.: Cranio-Facial Reconstruction and Otolaryngology
Cranial base surgery can involve removing the patient's eye sockets, cheeks, nose and/or mouth to reach the tumor. The skull base houses many cranial nerves that are responsible for functions such as sight, movement of the eye, swallowing, facial sensations and movement, hearing, balance, mastication and phonation, any of which may be adversely affected by tumors. An important aspect of tumor treatment is return of the patient to optimal function and cosmetics aesthetics.

Dr. Costantino, Co-Director of SLR's new Center for Cranial Base Surgery, is an expert in facial re-assemblage and optimal restoration of function and cosmetic aesthetics. He is recognized as a world leader in the field of head and neck oncology and has made numerous contributions to the otolaryngology specialty. Dr. Costantino excels in cranial defect and facial reconstruction involving implants and micro-vascular surgery of the jaw, mid-face and palate. Dr. Costantino was formerly co-director of the Cranial Base Surgery Program in the departments of otolaryngology and neurosurgery at the Mount Sinai School of Medicine, as well as associate professor of neurosurgery and oral and maxillofacial surgery. He is Joint Council Certified in Head and Neck Surgery and in Facial Plastic and Reconstructive Surgery.

Tissue Engineering
As a leading researcher in the field of tissue engineering, Dr. Costantino has developed biomaterials: synthetic tissues that combine with the patient's own bone growth enzymes to generate new bone. He has spearheaded the invention and development of two new reconstructive implants that have contributed to functional and aesthetic restoration of patients worldwide. One material is Hydroxyapatite cement, which can be likened to a plaster of paris compound, and is used as a foundation for bone regeneration, facilitating previously impossible cranio-facial repairs and reconstruction. The other is a unique soft tissue implant (a highly processed acellular dermis) that is ultimately replaced by living soft tissues as blood vessels grow into the edges of the implant. The benefits of these innovations include quick response of the patient's internal healing system, lower disease rate, and dramatically reduced external scar formation and oral deformity. Dr. Costantino is also the first surgeon to regrow a missing segment of jawbone in a human using distraction osteogenesis.

Facial Nerve Rehabilitation
Dr. Costantino's expertise also focuses on facial nerve rehabilitation following cranial-facial surgery, and also for patients with nerve disorders resulting from stroke, Bell's Palsy, acoustic neuroma, trauma and congenital problems. Treatable disorders include facial paralysis, eye movement problems and cosmetic rehabilitation.

St. Luke's-Roosevelt Hospital Center
St. Luke's-Roosevelt Hospital Center has a rich tradition of serving the community for more than one hundred years. As a major teaching hospital of Columbia University College of Physicians and Surgery, the hospital provides a full continuum of care. A founding member of Continuum Health Partners, its patients benefit from the vast network of clinical and administrative resources available through an extraordinary partnership with Beth Israel Medical Center, Long Island College Hospital and New York Eye & Ear Infirmary. Dr. Sen and his team will work closely with their colleagues at Beth Israel's Institute for Neurology and Neurosurgery (The INN), one of the world's leading centers for the diagnosis and treatment of complex neurosurgical and neuralgic problems.

Information
For more information about the Center for Cranial Base Surgery, or the Minimally Invasive Spine Center at St. Luke's-Roosevelt Hospital Center, please call (212) 523-6720/Fax: (212) 523-6115. The office is located at: 425 West 59 Street, NY, NY.


BIOGRAPHICAL SKETCHES

Chandranath Sen, M.D.
Dr. Sen is a diplomate of the American Board of Neurological Surgery, and a member of numerous professional associations, including the Congress of Neurological Surgeons, the New York State Neurological Society and the Joint Section on Tumors of the American Association of Neurological Surgeons. He founded and currently serves as director-at-large for the North American Skull Base Society. He has developed novel surgical techniques for the treatment of complex cranial base tumors and other issues.

Having worked extensively with the pioneer of microvascular decompression, Dr. Peter Jannetta, Dr. Sen is highly experienced and has done innovative research in the treatment of trigeminal neuralgia and hemifacial spasm. After attending medical school at MS University in Baroda, India, Dr. Sen completed a surgical internship in New Jersey at Middlesex General Hospital and Robert Wood Johnson Memorial Hospital. He followed this with general surgery and neurological surgery residencies at the University of Wisconsin Hospital, a microneurosurgery fellowship at the University of Pittsburgh, Presbyterian University Hospital in Pittsburgh, and a visiting fellowship at National Hospitals for Nervous Disorders in London.

Noel I. Perin, M.D., FRCS (Ed), FACS
Dr. Perin has international training in neurosurgery and orthopedics. He received his M.D. from the University of Sri Lanka (Colombo) and post-graduate training in the United Kingdom, serving first as house officer in general surgery in the Chelmsford Hospitals in Essex, England, then as a fellow in neurosurgery at the Middlesex Hospital in London. He completed a residency in neurosurgery at New York University Medical Center, followed by a combined neurosurgical and orthopedic fellowship at NYU in spinal surgery. He completed training in elective spinal neurosurgery at the Praacelsus Klinik in Osnerbrook, Germany. Before joining Mt. Sinai Medical Center, Dr. Perin was Assistant Professor of Neurosurgery and Director, Neuro-trauma at the University of Cincinnati Mayfield Neurological Institute. He was certified by the American Association of Neurological Surgeons in 1995, and has served on their spine section scientific and credentialing committees.

Peter D. Costantino, M.D., FACS
Dr. Costantino graduated Northwestern University Medical School in Chicago, where he also completed a surgical internship, residencies in otolaryngology and general surgery, and an American Cancer Society fellowship in head and neck surgical oncology and reconstructive surgery. He followed with a second fellowship in cranial base surgery at the University of Pittsburgh Medical School. He is Board Certified in Otolaryngology Head and Neck Surgery and in Facial Plastic and Reconstructive Surgery.

Dr. Costantino is a two-time recipient of the American Academy of Facial Plastic and Reconstructive Surgery Ira Tresley Award, and the Plastic Surgery Education Foundation Millard Award, presented for the most outstanding research in facial plastic and reconstructive surgery. His clinical research achievements to date include the first application of cellular dermis for the repair of dural defects and for soft tissue defects in humans. He is also the co-developer of Hydroxyapatite cement for cranio-facial reconstruction.